Protein database searches for multiple alignments.
نویسندگان
چکیده
منابع مشابه
DbClustal: rapid and reliable global multiple alignments of protein sequences detected by database searches.
DbClustal addresses the important problem of the automatic multiple alignment of the top scoring full-length sequences detected by a database homology search. By combining the advantages of both local and global alignment algorithms into a single system, DbClustal is able to provide accurate global alignments of highly divergent, complex sequence sets. Local alignment information is incorporate...
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Analyses of more distantly related HIV and SIV sequences that take as their point of departure an alignment, either of the nucleic acid or amino acid sequences, will only be as sound as the alignment, which is itself an hypothesis. For this reason, many sequence analyses are conducted over only “unambiguously alignable” stretches of sequence, typically stretches for which the similarities are 5...
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The database of multiple alignments for protein structures (DMAPS) provides instant access to pre-computed multiple structure alignments for all protein structure families in the Protein Data Bank (PDB). Protein structure families have been obtained from four distinct classification methods including SCOP, CATH, ENZYME and CE, and multiple structure alignments have been built for all families c...
متن کاملScores for sequence searches and alignments.
Every sequence comparison method requires a set of scores. For aligning protein sequences, substitution scores are based on models of amino acid conservation and properties, and matrices of these scores have substantially improved in recent years. Position-specific scoring matrices provide representations of sequence families that are capable of detecting subtle similarities. Comprehensive eval...
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The Protein Information Resource (PIR) has been maintaining a database of curated protein sequence alignments since 1991. The collection includes superfamily, family and homology domain alignments. CLUSTAL V/W is used to generate multiple sequence alignments and ALNED, an interactive alignment editor, is used to check and correct them. The database has helped in classifying sequences, in defini...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1990
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.87.14.5509